And Then Nothing Turned Itself Inside-Out was recorded at Alex the Great in Nashville, Tennessee and mixed at the Big House in Manhattan, New York City. The album was produced by Roger Moutenot and released on February 22, 2000 by Matador Records. The title of the album is likely derived from a Sun Ra quote: "...At first there was nothing...then nothing turned itself inside-out and became something". The album artwork is made up of photographs by surrealist photographer and Yale professor Gregory Crewdson. As of January 2003, the album has sold 114,000 copies in the U.S. according to Nielsen SoundScan.